Learn About PrEP & PEP Options That Can Help Prevent HIV
HIV Prevention Is More Accessible Than Ever
HIV prevention has never been more convenient or safer. In 2025, you have several highly effective medications at your disposal to reduce your risk of acquiring HIV. Whether you need a pill taken daily, a long-acting injection, or a one-dose emergency pill after exposure, there’s something for every lifestyle.
At STD Free Los Angeles, we’re committed to informing you of your options and giving you access to the care you need—cheaply and anonymously.
What Are PrEP and PEP?
PrEP (Pre-Exposure Prophylaxis)
PrEP is a preventive medication for an HIV-negative person that is taken before potential exposure to HIV. It is very effective if taken as directed and regularly. PrEP comes in both once-a-day oral tablets and long-acting injections.
PEP (Post-Exposure Prophylaxis)
PEP is a rescue HIV prevention pill. You must take PEP within 72 hours after possible HIV exposure and for 28 days. PEP is a good option if you think you have been exposed to HIV and were not practicing other methods of prevention.
Top HIV Prevention Medications in 2025
1. Descovy (emtricitabine/tenofovir alafenamide)
- Type: Daily PrEP (Oral pill)
- Approved For: HIV-negative individuals excluding those at risk from receptive vaginal sex
- Pros:
- Fewer side effects on kidneys and bones than Truvada
- Convenient once-daily pill
- Cons:
- Not approved for individuals at risk via vaginal sex
2. Truvada (emtricitabine/tenofovir disoproxil fumarate)
- Type: Daily PrEP (Oral pill)
- Approved For: All HIV-negative individuals at risk
- Pros:
- Most studied and widely used PrEP option
- Approved for all genders and risk groups
- Cons:
- Potential for bone and kidney side effects with long-term use
3. Apretude (cabotegravir injectable)
- Type: Long-Acting Injectable PrEP
- Schedule: Every 2 months via injection
- Approved For: Adults and adolescents at risk for HIV
- Pros:
- No daily pills—ideal for people with adherence challenges
- Clinically shown to be as effective or more effective than oral PrEP
- Cons:
- Must receive injections at a clinic or doctor’s office
- Requires regular appointments
4. PEP (Post-Exposure Prophylaxis)
- Type: Emergency treatment started within 72 hours after exposure
- Common Regimen: Truvada + Isentress or Truvada + Tivicay
- Duration: 28 days of treatment
- How It Works: Stops the virus from replicating before it takes hold
When to Use PEP:
- Condom breaks during sex
- Shared needles or injection equipment
- Sexual assault
- Unprotected sex with a partner whose HIV status is unknown or positive
Important: PEP must be started within 3 days (72 hours) of exposure. The sooner you start, the more effective it is.
Required Tests Before Starting PrEP or PEP
Before starting any HIV prevention medication, it’s important to undergo specific tests to make sure the treatment is safe and appropriate for you.
Mandatory Blood Tests:
| Test | Purpose | Minimum Requirement |
|---|---|---|
| HIV Test | Confirm HIV-negative status | Must be Negative |
| Creatinine & eGFR | Check kidney function | CrCl ≥ 60 for Truvada, ≥ 30 for Descovy |
| Liver Panel | Ensure healthy liver | Normal AST/ALT |
| Hepatitis B & C Antibodies | Assess liver risk if stopping meds | Stable/negative |
| Pregnancy Test | If applicable | Not pregnant or medically cleared |
| STI Screening | Assess risk and co-infections | Recommended, not required |
Which Medication Is Right for Me?
Choosing the right HIV prevention method depends on your lifestyle, health status, and sexual activity. Here’s a quick comparison:
| Medication | Dosing Schedule | Key Benefit |
|---|---|---|
| Truvada | Daily | Widely available and studied |
| Descovy | Daily | Less strain on kidneys and bones |
| Apretude | Every 2 months | No pills to remember |
| PEP | 28-day course | Emergency use only |
Access HIV Prevention in Los Angeles
STD Free Los Angeles is dedicated to helping you get PrEP or PEP quickly and discreetly. Whether you’re looking for a long-term prevention plan or need emergency help after exposure, our medical providers can guide you through every step.
What We Offer:
- Same-Day PEP Access
- PrEP Prescriptions & Refills
- Free or Low-Cost Testing
- Telehealth Appointments
- Confidential Services
How to Get Started
- Schedule a HIV Test
We offer rapid HIV testing with results in minutes. - Talk to a Provider
Discuss your lifestyle, risk factors, and which prevention option is best for you. - Get Your Prescription
Pick up PrEP from a nearby pharmacy or get started on PEP immediately if you’ve been exposed.
Why HIV Prevention Matters
One exposure to HIV may lead to a lifelong infection. The good news? PrEP reduces the risk of getting HIV by over 99% via sex and 74% via injection drug use when taken every day.
If you suspect that you’ve been infected with HIV, don’t delay. Seek testing and begin PEP immediately within 72 hours.
If you think you’ve been exposed to HIV, don’t wait. Get tested and start PEP within 72 hours.
Your Privacy Comes First
At STD Free Los Angeles, we understand that these are sensitive topics. That’s why we offer:
- Confidential services
- LGBTQ+ inclusive care
- Judgment-free support
- Affordable pricing and help with insurance or payment
Book Your Appointment Today
Prevention starts with a conversation. Whether you’re new to PrEP, need emergency PEP, or just want to learn more, we’re here to help.